Cancer Therapy: Preclinical Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies
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چکیده
Purpose: To develop an adaptable gene-based vector that will confer immune cell specificity to various
منابع مشابه
Redirecting gene-modified T cells toward various cancer types using tagged antibodies.
PURPOSE To develop an adaptable gene-based vector that will confer immune cell specificity to various cancer types. EXPERIMENTAL DESIGN Human and mouse T cells were genetically engineered to express a chimeric antigen receptor (CAR) that binds a fluorescein isothiocyanate (FITC) molecule, termed anti-FITC CAR T cells. Various antibodies (Ab) currently in clinical use including cetuximab (Ctx)...
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تاریخ انتشار 2012